Vol. 38 No. 5 (2021): Octubre
Original Article

Genetic diversity of M. tuberculosis circulating in the jurisdiction V from Jalapa, Veracruz, Mexico

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  • Betchaah Lefort,
  • Damián Pérez-Martínez,
  • Roberto Zenteno-Cuevas,
  • Diana Viveros
Betchaah Lefort
Instituto de Salud Pública de la Universidad Veracruzana, México
Bio
Damián Pérez-Martínez
Instituto de Ciencias de la Salud. Universidad Veracruzana, Veracruz
Bio
Roberto Zenteno-Cuevas
Instituto de Salud Pública, Universidad Veracruzana. Av. Luis Castelazo Ayala s/n, A.P. 57 Col. Industrial Ánimas. Xalapa, Veracruz, 91190, México
Diana Viveros
Universidad Veracruzana. Veracruz
Bio

Published 2021-11-18

Keywords

How to Cite

1.
Lefort B, Pérez-Martínez D, Zenteno-Cuevas R, Viveros D. Genetic diversity of M. tuberculosis circulating in the jurisdiction V from Jalapa, Veracruz, Mexico. Rev. Chilena. Infectol. [Internet]. 2021 Nov. 18 [cited 2026 Mar. 13];38(5). Available from: https://revinf.cl/index.php/revinf/article/view/1158

Copyright (c) 2021 Betchaah Lefort, Damián Pérez-Martínez, Roberto Zenteno-Cuevas, Diana Viveros

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Background: The state of Veracruz is placed in southeastern Mexico and has a high prevalence of tuberculosis (TB) and drug resistance. Nevertheless, the composition of circulating genotypes in the central region of the state is partially known. Aim: To characterize the genetic diversity of TB in the sanitary jurisdiction V of the state of Veracruz.

Methods: A cross-sectional study was conducted among clinical isolates from patients with TB living in the jurisdiction V, in Jalapa Ver., Mexico. Sensitivity to first-line drugs was determined, and genotyping was performed by spoligotyping and MIRU-VNTR 15 loci. Results: Among the 74 isolates analyzed, resistance to one drug was observed in 44 isolates. L4 (EuroAmerican) was the major lineage identified. Five sublineages were the most abundant; H (40%), T (22%), LAM (16%), X (13%) and U (7%). Only 32% of the isolates were clustered by spoligotype and 40% were placed in ten clonal complexes. Conclusions: This is the first description of the genetic structure of TB in the central region of Veracruz. The diversity of genotypes could contribute to its dispersion. This information will be useful for the development of interventions to reduce the impact of TB in the population.
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