Vol. 38 No. 5 (2021): Octubre
Short Communication

Detection of anti-virus hepatitis e IgG and IgM antibodies using an automated method: experience of a university hospital

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  • Natalia Covarrubias,
  • Constanza Bohle,
  • Christian Lara,
  • Julio Miranda,
  • Carmen Hurtado,
  • Mauricio Venegas
Natalia Covarrubias
Hospital Clínico Universidad de Chile

Published 2021-11-18

Keywords

How to Cite

1.
Covarrubias N, Bohle C, Lara C, Miranda J, Hurtado C, Venegas M. Detection of anti-virus hepatitis e IgG and IgM antibodies using an automated method: experience of a university hospital. Rev. Chilena. Infectol. [Internet]. 2021 Nov. 18 [cited 2026 Mar. 13];38(5). Available from: https://revinf.cl/index.php/revinf/article/view/1166

Copyright (c) 2021 Natalia Covarrubias, Constanza Bohle, Christian Lara, Julio Miranda, Carmen Hurtado, Mauricio Venegas

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

The determination of anti-hepatitis E virus antibodies (anti-HEV) has a high variability depending on the assay used. In 2015, with a manual ELISA method, we reported anti-HEV IgG seroprevalence of 32.6% in patients under hepatitis study. There are few reports of anti-HEV IgM. Recently, it was developed the first automated method and in the present study, we report the experience using this new method. Between May 2018 and August 2020, the results of 272 patients with an anti-HEV IgG and/or IgM study were analyzed using the automated ELFA technique (VIDAS®). Seroprevalence was 25.8% (68/264) for anti-HEV IgG and 3.5% (9/259) for anti-HEV IgM. Four samples were positive for both antibodies. Anti-HEV IgG seropositivity increased with age. In conclusion, the seroprevalence of anti-HEV IgG obtained was similar to previously reported. Taking into account the advantages of these assays, anti-HEV IgM and IgG assays on VIDAS® system, seem to be valuable new tools in serological study of HEV.

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