Factors associated with tuberculosis mortality in indigenous people in Paraguay, 2014 to 2019

Abstract

Background: The estimated tuberculosis (TB) mortality rate in Paraguay in 2019 was 3.9 per 100,000 people. Indigenous communities are at high risk for TB. Aim: To determine the factors associated with mortality in indigenous people with a diagnosis of TB in Paraguay, 2014-2019. Methods: A retrospective observational study was done. sociodemographic data and risk factors data from the National TB Program of Paraguay between the years 2014 to 2019 were used. Results: A total of 2,210 indigenous people with a diagnosis of TB were included, 53,8% were male, between 20 to 39 (32.3%) and 0 to 19 years old (30.2%), the localization of TBC was majority pulmonary (92,3%). During 2014 to 2019 the were 217 deaths (9,8%). The factors associated to mortality in TB patients were the age (_adOR=13.95; CI: 7.07 - 27.55 older than 80 years), (_adOR=4.20; CI: 2.59 - 6.82 older than 60 years), and (_adOR=3.30; CI: 2.06 - 5.2840 to 59 years), HIV co-infection (_adOR=7.07; CI 3.74-13.87), and localization of TB (_adOR=3.60; CI: 1.88-6.90 for disseminated TB). Conclusion: Older age, HIV co-infection and disseminated localization of TBC are associated with a higher risk of death in indigenous people with TB.