Vol. 39 No. 4 (2022): August
Review Article

Hepatitis of unknown etiology in pediatric population

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  • Aline Jorquera L.,
  • Jan Wilhelm B.,
  • Natalia Conca R.
Aline Jorquera L.
Hospital Luis Calvo Mackenna
Jan Wilhelm B.
Hospital Luis Calvo Mackenna
Natalia Conca R.
Hospital Luis Calvo Mackenna

Published 2022-10-04

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How to Cite

1.
Jorquera L. A, Wilhelm B. J, Conca R. N. Hepatitis of unknown etiology in pediatric population. Rev. Chilena. Infectol. [Internet]. 2022 Oct. 4 [cited 2025 Nov. 6];39(4). Available from: https://revinf.cl/index.php/revinf/article/view/1656

Copyright (c) 2022 Aline Jorquera L., Jan Wilhelm B., Natalia Conca R.

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

In recent months there has been an increase in cases reports of hepatitis of unknown origin. The most affected population are children under 5 years of age, but it has been described in adolescents up to 16 years of age. The clinical presentation consists of cholestatic hepatitis with a prodrome of diarrhea, nausea, and vomiting. Prognosis is generally benign but, on average, 13% of patients have required admission to an intensive care unit and 10% a liver transplant. Etiological studies have associated this entity to adenoviral infections, but hypotheses include other infectious agents, either as a triggering factor or as its main etiology, toxins, and even immunizations against SARS-CoV-2. In the following review we present the data available to date regarding the different pathogenesis theories.
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