Vol. 40 No. 3 (2023): Junio
Review Article

Immunological response to vaccination and risk of COVID-19 in adults with hematological malignancies

Jorge Alberto Cortes
Universidad Nacional de Colombia
Bio
Laura Cristina Nócua-Báez
Universidad Nacional de Colombia, programa de Infectología
Bio
Candida Díaz-Brochero
Hospital Universitario Nacional de Colombia, Unidad de Infectología
Bio
Sonia Isabel Cuervo-Maldonado
Universidad Nacional de Colombia, Instituto Nacional de Cancerología
Bio

Published 2023-06-30

How to Cite

1.
Cortes JA, Nócua-Báez LC, Díaz-Brochero C, Cuervo-Maldonado SI. Immunological response to vaccination and risk of COVID-19 in adults with hematological malignancies. Rev. Chilena. Infectol. [Internet]. 2023 Jun. 30 [cited 2026 Jun. 2];40(3). Available from: https://revinf.cl/index.php/revinf/article/view/1696

Abstract

Patients with hematological malignancies have a higher risk of hospital admission, critical care and death when they suffer from COVID-19. In this group of patients, vaccination and boosters have been proposed to mitigate the risk of complications. However, it is possible to observe a diminished rate of humoral and cellular response. In this review, evidence is shown about the response to COVID-19 vaccination, considering some specific pathologies and treatments that can affect such response in a significant account. Patients with malignant neoplasm must be considered at risk of COVID-19 complications, even after a complete vaccine schedule and boosters. Surveillance must be maintained after vaccination over these patients and other strategies must be considered (drugs, monoclonal antibodies) for prevention and management of COVID-19.