Posología de antimicrobianos en terapia de reemplazo renal continua, una revisión

Abstract

Background: Thirty percent of patients admitted to intensive care units require the use of renal replacement therapies mainly due to septic processes, with continuous renal replacement therapy (CRRT), being indicated over intermittent dialysis therapy. CRRT is characterized by removing uremic compounds, proinflammatory and medications, producing variations in the pharmacokinetics of the drug and therefore, in the therapeutic response. Given the indication of CRRT in the patient in critical care, the dosage of antimicrobials is considered of high relevance in order to reduce morbidity and mortality in this population. Aim: To systematize the existing information on the influence of CRRT on the pharmacokinetics of the antimicrobial and thus determine dosage recommendations in these patients.