Vol. 37 No. 6 (2020)
Clinical Research

Clinical-epidemiological characterization of neonatal necrotizing enterocolitis of seven public hospitals

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  • Alejandra Sandoval,
  • Fernanda Cofré Segovia,
  • Mariluz Hernández Escobar,
  • Gianina Izquierdo Copiz,
  • Yenis Labraña Cornejo,
  • Alejandra Reyes Jiménez,
  • Hector Pérez Álvarez,
  • Scarleth Brethauer Meier,
  • Miguel Ángel Pantoja Herrera,
  • Christina Lindemann Tappert,
  • Gustavo Orellana Sandoval,
  • Carolina Méndez Benavente,
  • Adela Figueroa Bruna,
  • Jaime Cerda Lorca,
  • Luis Delpiano Méndez
Alejandra Sandoval
Complejo Asistencial Dr. Sótero del Río Actuaalmente Hospital Carlos Van Buren, Valparaíso
Fernanda Cofré Segovia
Hospital San José
Mariluz Hernández Escobar
Hospital Santiago Oriente Dr. Luis Tisné Brousse
Gianina Izquierdo Copiz
Complejo Asistencial Barros Luco Trudeau
Yenis Labraña Cornejo
Hospital San Juan De Dios
Alejandra Reyes Jiménez
Hospital Felix Bulnes Cerda
Hector Pérez Álvarez
Complejo Asistencial Dr. Sótero Del Río
Scarleth Brethauer Meier
Hospital San José
Miguel Ángel Pantoja Herrera
Hospital San Borja Arriarán
Christina Lindemann Tappert
Hospital La Florida
Gustavo Orellana Sandoval
Complejo Asistencial Barros Luco Trudeau
Carolina Méndez Benavente
Hospital San Juan De Dios
Adela Figueroa Bruna
Hospital Felix Bulnes
Jaime Cerda Lorca
Pontificia Universidad Católica de Chile
Bio
Luis Delpiano Méndez
Hospital San Borja Arriarán

Published 2021-01-15

Keywords

How to Cite

1.
Sandoval A, Cofré Segovia F, Hernández Escobar M, Izquierdo Copiz G, Labraña Cornejo Y, Reyes Jiménez A, Pérez Álvarez H, Brethauer Meier S, Pantoja Herrera M Ángel, Lindemann Tappert C, Orellana Sandoval G, Méndez Benavente C, Figueroa Bruna A, Cerda Lorca J, Delpiano Méndez L. Clinical-epidemiological characterization of neonatal necrotizing enterocolitis of seven public hospitals. Rev. Chilena. Infectol. [Internet]. 2021 Jan. 15 [cited 2026 May 24];37(6). Available from: https://revinf.cl/index.php/revinf/article/view/220

Copyright (c) 2021 Alejandra Sandoval, Fernanda Cofré Segovia, Mariluz Hernández Escobar, Gianina Izquierdo Copiz, Yenis Labraña Cornejo, Alejandra Reyes Jiménez, Hector Pérez Álvarez, Scarleth Brethauer Meier, Miguel Ángel Pantoja Herrera, Christina Lindemann Tappert, Gustavo Orellana Sandoval, Carolina Méndez Benavente, Adela Figueroa Bruna, Jaime Cerda Lorca, Luis Delpiano Méndez

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Background: Necrotizing enterocolitis (NEC) presents high mortality and postoperative, gastrointestinal and neurodevelopmental morbidity. There is limited information about NEC in Chile. Aim: To describe the clinical/epidemiological behavior of newborns who underwent NEC. Methods: Multicenter descriptive study of patients with NEC from seven hospitals of Santiago, Chile, during 2016. Descriptive statistics and univariate/multivariate analysis were performed (SPSS v22 software). Results: 75 cases were collected. Median days of life at diagnosis was 11, gestational age was 29 weeks, birth weight 1,114gr. The incidence was 2.6 per 1,000 live newborns and mortality was 18.6%, higher in ≤750g, ≤25 weeks and surgical NEC. There was 45.3% microbiological isolation and 19 different empirical antibiotic schemes were used for the treatment of NEC. The multivariate analysis showed a higher risk of surgery in umbilical arterial catheter users, CRP >10mg/L and positive microbiological isolation. The highest risk of death was in umbilical arterial catheter users. Discussion: This ie the first multicenter study that collects local data information. The incidence was similar to that found in medical reports but with a lower mortality. There is no consensus of antibiotic treatment to use. With these results we hope to advance in improving the diagnosis and unify antimicrobial treatments, to reduce morbidity and mortality figures.

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