Vol. 36 No. 5 (2019): October
Clinical Expreience

Clinical- epidemiological characteristics and predictors of coronary complications in children of Argentina with Kawasaki disease

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  • Pablo Andrés Melonari,
  • Héctor Abate,
  • Luis Hernán Llano López,
  • Rubén J. Cutica,
  • M. Teresa Apaz,
  • Cristina Battagliotti,
  • Iris Vilca,
  • Aldo Cancellara,
  • Miriam Calvari,
  • Alejandro Ellis,
  • Adrián G. Collia,
  • Luis Pedro Flynn,
  • Alicia Aletti,
  • Gustavo Lazarte,
  • Juan Petricca,
  • Ivana P. Tonetto,
  • Alejandro Santillán,
  • Mariana Brusadín,
  • Alejandra Gaiano,
  • Leonardo Mannino,
  • Virginia Bonardo,
  • Cristina Euliarte,
  • Norberto De Carli,
  • Luciana Bellone,
  • Andrea Gajo-Gané,
  • Ana Albano
Pablo Andrés Melonari
Hospital Humberto Notti
Bio

Published 2019-11-25

Keywords

How to Cite

1.
Melonari PA, Abate H, Llano López LH, Cutica RJ, Apaz MT, Battagliotti C, Vilca I, Cancellara A, Calvari M, Ellis A, Collia AG, Flynn LP, Aletti A, Lazarte G, Petricca J, Tonetto IP, Santillán A, Brusadín M, Gaiano A, Mannino L, Bonardo V, Euliarte C, De Carli N, Bellone L, Gajo-Gané A, Albano A. Clinical- epidemiological characteristics and predictors of coronary complications in children of Argentina with Kawasaki disease. Rev. Chilena. Infectol. [Internet]. 2019 Nov. 25 [cited 2025 Dec. 19];36(5). Available from: https://revinf.cl/index.php/revinf/article/view/230

Copyright (c) 2019 Pablo Andrés Melonari, Héctor Abate, Luis Hernán Llano López, Rubén J. Cutica, M. Teresa Apaz, Cristina Battagliotti, Iris Vilca, Aldo Cancellara, Miriam Calvari, Alejandro Ellis, Adrián G. Collia, Luis Pedro Flynn, Alicia Aletti, Gustavo Lazarte, Juan Petricca, Ivana P. Tonetto, Alejandro Santillán, Mariana Brusadín, Alejandra Gaiano, Leonardo Mannino, Virginia Bonardo, Cristina Euliarte, Norberto De Carli, Luciana Bellone, Andrea Gajo-Gané, Ana Albano

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Background: Kawasaki disease (EK) is an acute systemic vasculitis with a risk of developing coronary aneurysms. Aim: To describe the clinical and epidemiological characteristics of children with EK in Argentina and to analyse the risk factors for the development of coronary’s complications (CC). Methods: Multicenter, retrospective, cross-sectional, observational and analytical study. It included patients younger than 18 years of age diagnosed with EK in hospitals in Argentina, between January the 1st, 2010 and December the 31th, 2013. Results: N = 193 subjects. Age: medium: 29 months. Total incidence 5 cases / 10,000 hospital discharges. CC was observed in 15.5% of patients. Increased risk factors for CC: Elevated number of days with fever at the time of treatment placement (p = 0.0033); Increased of: heart frequency (p = 0.0021), erythrosedimentation (ESR) (p = 0.005), C-reactive protein (CRP) (p < 0.0001), leukocytes (p = 0.0006), neutrophils (p = 0.0021); Decreased of hematocrit (p = 0.0007) and hemoglobin (p < 0.0001).Association with CC: non-coronary cardiological alterations (OR = 10,818); PCR greater than 68 mg /L (OR = 11,596); leukocytes greater than 20,000 / mm3 (OR = 4.316); and ESR greater than 64 mm / 1 hour (OR = 4.267). Conclusion: The most frequent form of presentation was complete EK, the risk of CC was higher in males, younger than 5 years old, the risk factors (clinical and laboratory) were similar to those described in the literature.
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