Vol. 42 No. 6 (2025): December
Clinical Expreience

RSV, influenza, and SARS-CoV-2 infection among older adults hospitalized in a medical center from Argentina

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  • Maria Victoria Vulcano,
  • Bettina Cooke,
  • Juan P. Balbuena,
  • Agustín Romandetta,
  • Mara Ruso,
  • Elsa Baumeister,
  • Andrea Pontoriero,
  • María Fernanda Alzogaray,
  • Esteban C. Nannini,
  • Analía Mykietiuk
Maria Victoria Vulcano
Instituto Medico Platense
Bio
Bettina Cooke
1Grupo Sur, Instituto Médico Platense, La Plata, Buenos Aires, Argentina
Juan P. Balbuena
1Grupo Sur, Instituto Médico Platense, La Plata, Buenos Aires, Argentina
Agustín Romandetta
Grupo Sur, Instituto Médico Platense, La Plata, Buenos Aires, Argentina
Mara Ruso
2Servicio de Virosis Respiratorias, INEI-ANLIS Dr. Carlos G. Malbrán, Buenos Aires, Argentina
Elsa Baumeister
2Servicio de Virosis Respiratorias, INEI-ANLIS Dr. Carlos G. Malbrán, Buenos Aires, Argentina
Andrea Pontoriero
2Servicio de Virosis Respiratorias, INEI-ANLIS Dr. Carlos G. Malbrán, Buenos Aires, Argentina
María Fernanda Alzogaray
1Grupo Sur, Instituto Médico Platense, La Plata, Buenos Aires, Argentina
Esteban C. Nannini
Instituto Médico Platense, La Plata, Buenos Aires, Universidad Nacional de Rosario, Instituto IDICER, Rosario,
Analía Mykietiuk
Grupo Sur, Instituto Médico Platense, La Plata, Buenos Aires,
DOI: https://doi.org/10.4067/s0716-10182025000600187

Published 2025-11-26

How to Cite

1.
Vulcano MV, Cooke B, Balbuena JP, Romandetta A, Russo M, Baumeister E, Pontoriero A, Alzogaray MF, Nannini EC, Mykietiuk A. RSV, influenza, and SARS-CoV-2 infection among older adults hospitalized in a medical center from Argentina. Rev. Chilena. Infectol. [Internet]. 2025 Nov. 26 [cited 2025 Dec. 19];42(6). Available from: https://revinf.cl/index.php/revinf/article/view/2358

Copyright (c) 2025 Maria Victoria Vulcano

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Background: Influenza virus, SARS-CoV-2, and respiratory syncytial virus (RSV) are the main causative agents of acute respiratory infections (ARI) in older adults. Aim: To compare risk factors, presentation, and progression in older adults hospitalized with infection by these viruses. Methods: Prospective observational study of patients aged ≥65 years with ARI admitted to a hospital in La Plata, Argentina, from April 2018 to December 2020. Demographic data, comorbidities, and clinical outcomes were collected. Molecular diagnosis of RSV, influenza, and SARS-CoV-2 was performed using RT-PCR on respiratory samples. Results: Of 448 patients with ARI, 45%, 17%, and 16% tested positive for SARS-CoV-2, RSV, and influenza, respectively. The average age was 82 years, and 51% were female. Patients with RSV more frequently had a history of bronchial asthma or cardiovascular disease, presented clinically with asthma/COPD exacerbation, and had no fever. 30-day mortality was higher in patients with SARS-CoV-2 (42%) than in patients with RSV (25%) and influenza (27%); however, this difference was not statistically significant. Discussion: Influenza and RSV infections were associated with significant mortality in older adults. Greater awareness of the impact of influenza and particularly RSV on this population is needed to promote preventive measures.

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