Vol. 43 No. 1 (2026): February
Clinical Case

Photosensitivity induced by dolutegravir, lamivudine, and tenofovir in a patient living with HIV

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  • Sofia Gomez- Barris Ortiz,
  • Fernanda Echeverria,
  • Miquela Martinez,
  • Andres Figueroa
Sofia Gomez- Barris Ortiz
Universidad de los Andes
Fernanda Echeverria
Universidad de los Andes
Andres Figueroa
Clinica Davila
DOI: https://doi.org/10.4067/s0716-10182026000100106

Published 2026-01-20

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How to Cite

1.
Gomez- Barris Ortiz S, Echeverria F, Martinez M, Figueroa A. Photosensitivity induced by dolutegravir, lamivudine, and tenofovir in a patient living with HIV. Rev. Chilena. Infectol. [Internet]. 2026 Jan. 20 [cited 2026 Feb. 1];43(1). Available from: https://revinf.cl/index.php/revinf/article/view/2493

Copyright (c) 2026 Sofia Gomez- Barris Ortiz, Fernanda Echeverria, Miquela Martinez, Andres Figueroa

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Photosensitivity induced by dolutegravir, lamivudine, and tenofovir, a drug combination frequently used in people living with HIV is a rarely documented adverse reaction, particularly with orally administered drugs. We present the case of an 87-year-old patient who developed persistent cutaneous lesions after one year of antiretroviral therapy (ART). Histological analysis of a skin biopsy revealed photosensitive dermatitis. Discontinuation of ART and its replacement with raltegravir, emtricitabine, and tenofovir resulted in complete clinical recovery. This case highlights the importance of considering photoallergic reactions in the differential diagnosis of dermatitis affecting sun-exposed areas in individuals undergoing ART. It also underscores the need for continuous clinical monitoring to optimize safety and long-term treatment adherence.

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