Vol. 35 No. 5 (2018): October
Clinical Expreience

Pediatric clinical experience in infectious endocarditis due to Candida spp

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  • Pedro Antonio Martínez,
  • Martín Guerrero,
  • José Écil Santos,
  • María Santos Hernández,
  • Mónica Cecilia Mercado
Pedro Antonio Martínez
Hospital Civil de Guadalajara “Fray Antonio Alcalde”
Martín Guerrero
Hospital Civil de Guadalajara “Fray Antonio Alcalde”
José Écil Santos
Hospital Civil de Guadalajara “Fray Antonio Alcalde”
María Santos Hernández
Universidad de Guadalajara
Mónica Cecilia Mercado
Hospital Civil de Guadalajara “Fray Antonio Alcalde”

Published 2018-11-25

Keywords

How to Cite

1.
Martínez PA, Guerrero M, Santos J Écil, Santos Hernández M, Mercado MC. Pediatric clinical experience in infectious endocarditis due to Candida spp. Rev. Chilena. Infectol. [Internet]. 2018 Nov. 25 [cited 2025 Nov. 25];35(5). Available from: https://revinf.cl/index.php/revinf/article/view/254

Copyright (c) 2018 Pedro Antonio Martínez, Martín Guerrero, José Écil Santos, María Santos Hernández, Mónica Cecilia Mercado

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Background: Treatment and outcome of Candida spp infectious endocarditis in children it most be based on treatment guidelines, however there are some controversies. Aim: To describe our experience on treatment of pediatric candidal infective endocarditis. Methods: Analytic prospective study, from January 2006 to December 2017. Parametric analysis for quantitative variable. Proportions were compared by c2 and exact Fisher Test CI 95%. Mortality rate. Results: 25 episodes of Candida spp infective endocarditis were treated with standard antifungal drugs. Mortality rate was higher on patients submited to endocardic vegetation resection (66.7%) RR= 3.16, (c2 p = 0.029), children with lymphohemophagocytic syndrome (LHFS) (50 %) RR= 1.18 (c2 = N.S.), in multidrug resistant bacterial co infection (57.14%), RR = 2, (c2 = NS) also thrombotic endocarditis (88.9%) RR= 4.74 (c2 p = 0.004). Conclusion: Multidrug resistant bacteria co infection with Candida sp IE, LHFS, and/or surgical treatment of endocardic vegetation, might be considered as bad prognostic factors.
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