Vol. 43 No. 3 (2026): June (Next Issue)
Clinical Case

Eyelid necrosis with acute periorbital swelling: do not miss herpes simplex virus-1

  • Valentina Kurte Andrade,
  • Raúl Cabrera Moraga ,
  • Khanty Loyola Avila ,
  • Jorge Navarrete Cabello ,
  • Valeska Vollrath Reyes
Valentina Kurte Andrade
Médico cirujano, residente dermatología UDD
Raúl Cabrera Moraga
1. Departamento de Dermatología, Facultad de Medicina, Clínica Alemana - Universidad del Desarrollo, Santiago, Chile.
Khanty Loyola Avila
Bio
Jorge Navarrete Cabello
Bio
Valeska Vollrath Reyes
3. Departamento de Laboratorio Clínico, Facultad de Medicina, Clínica Alemana – Universidad del Desarrollo, Santiago, Chile.
Bio

Published 2026-05-18

Keywords

How to Cite

1.
Kurte Andrade V, Cabrera Moraga R, Loyola Avila K, Navarrete Cabello J, Vollrath Reyes V. Eyelid necrosis with acute periorbital swelling: do not miss herpes simplex virus-1. Rev. Chilena. Infectol. [Internet]. 2026 May 18 [cited 2026 May 25];43(3). Available from: https://revinf.cl/index.php/revinf/article/view/2589

Copyright (c) 2026 Valentina Kurte Andrade, Raúl Cabrera Moraga , Khanty Loyola Avila , Jorge Navarrete Cabello , Valeska Vollrath Reyes

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Herpes simplex virus type 1 (HSV-1) is a neurotropic virus classically associated with orolabial and ocular infections. Cutaneous necrosis is an uncommon manifestation, and to date, no cases of palpebral necrosis due to this agent have been reported. We present two cases of fulminant eyelid necrosis associated with HSV-1 infection, confirmed by PCR. In both patients, rapid resolution was observed following the timely initiation of antiviral therapy. This report expands the clinical spectrum of HSV-1 infection and highlights the importance of considering a herpetic etiology in the differential diagnosis of palpebral necrosis.