Vol. 34 No. 1 (2017)
Clinical Research

Cambios clínicos y epidemiológicos de candidemias en pacientes adultos desde 2000 a 2013

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  • Leonardo Siri,
  • Paulette Legarraga,
  • Patricia García,
  • Tamara González,
  • Ricardo Rabagliati

Keywords

How to Cite

1.
Siri L, Legarraga P, García P, González T, Rabagliati R. Cambios clínicos y epidemiológicos de candidemias en pacientes adultos desde 2000 a 2013. Rev. Chilena. Infectol. [Internet]. 2017 Mar. 31 [cited 2025 Nov. 26];34(1). Available from: https://revinf.cl/index.php/revinf/article/view/3

Copyright (c) 2017 Leonardo Siri, Paulette Legarraga, Patricia García, Tamara González, Ricardo Rabagliati

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Background: Invasive Candida spp. infections have been described more frequently. Aim: To characterize the epidemiological data of candidemia in recent years. Methods: A retrospective study of adult patients in a Uni-versity Hospital in Santiago, Chile, with 1 or more documented episodes of candidemia, from January 2000 to December 2013.

Results: One hundred and twenty episodes of candidemia were identifiedin 120 patients, annual incidence of 0.4 cases per 1000 discharges, 53.3% were male patients, 58.3% > 60 years, 77,5% had at least one co-morbidity. Candida albicans was the species most frequently identified55%, followed by C. glabrata 18.3%, C. tropicalis 11.7% and C. parapsilosis 9.2%. Comparing 2000-2006 vs 2007-2013, increased the frequency of C. parapsilosis among non-albicans and echinocandins prescription. Patients with C. albicans showed higher APACHE-II, more requirement for invasive mechanical ventilation, greater association with CVC, and shorter incubation time compared with non-albicans species. The 30-day mortality was 31.7%.

Conclusions: During this 14-years period we observed that C. albicans was the predominant specie and more recently a change among C. non-albicans increasing C. parapsilosis and decreasing C. glabrata 30-days and attributable mortality decreased together with more echinocandins prescription.

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