Vol. 36 No. 4 (2019): August
Clinical Research

Sociodemographic risk factors of hantavirus cardiopulmonary syndrome

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  • Cecilia Vial Cox,
  • Francisca Valdivieso R.,
  • Analía Cuiza V.,
  • Iris Delgado B.,
  • Grazielle Ribeiro E,
  • Elena Llop R.,
  • Marcela Ferrés G.,
  • Gabriela M. Repetto L.,
  • Raúl Riquelme O.,
  • M. Luisa Rioseco Z.,
  • Mario Calvo A.,
  • Gregory Mertz,
  • Pablo A. Vial C.
Cecilia Vial Cox
Clínica Alemana Universidad del Desarrollo
Bio
Francisca Valdivieso R.
Clínica Alemana Universidad del Desarrollo
Analía Cuiza V.
Clínica Alemana Universidad del Desarrollo
Iris Delgado B.
Clínica Alemana Universidad del Desarrollo
Grazielle Ribeiro E
Clínica Alemana Universidad del Desarrollo
Elena Llop R.
Universidad de Chile
Marcela Ferrés G.
Universidad Católica
Gabriela M. Repetto L.
Universidad San Sebastián
Raúl Riquelme O.
Universidad Austral de Chile
M. Luisa Rioseco Z.
Universidad Austral de Chile
Mario Calvo A.
University of New Mexico
Gregory Mertz
University of New Mexico
Pablo A. Vial C.
Clínica Alemana Universidad del Desarrollo

Published 2019-08-25

Keywords

How to Cite

1.
Vial Cox C, Valdivieso R. F, Cuiza V. A, Delgado B. I, Ribeiro E G, Llop R. E, Ferrés G. M, Repetto L. GM, Riquelme O. R, Rioseco Z. ML, Calvo A. M, Mertz G, Vial C. PA. Sociodemographic risk factors of hantavirus cardiopulmonary syndrome. Rev. Chilena. Infectol. [Internet]. 2019 Aug. 25 [cited 2026 Jun. 4];36(4). Available from: https://revinf.cl/index.php/revinf/article/view/302

Copyright (c) 2019 Cecilia Vial Cox, Francisca Valdivieso R., Analía Cuiza V., Iris Delgado B., Grazielle Ribeiro E, Elena Llop R., Marcela Ferrés G., Gabriela M. Repetto L., Raúl Riquelme O., M. Luisa Rioseco Z., Mario Calvo A., Gregory Mertz, Pablo A. Vial C.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Background: Hantavirus cardiopulmonary syndrome (HCPS) is caused by new world hantaviruses, among which Andes hantavirus (ANDV) is endemic to Chile and Southern Argentina. The disease caused by ANDV produces plasma leakage leading to enhanced vascular permeability and has a high case fatality rate (35%), mainly due to respiratory failure, pulmonary edema and myocardial dysfunction, hypoperfusion and shock. Host sociodemographic and genetic factors might influence the course and outcome of the disease. Yet, they have not been thoroughly characterized. Aim: To evaluate sociodemographic factors as risk factors in severity of HCPS. Patients and Methods: Study period: 2004-20013, attending in eight collaborative centers, etiological diagnosis was performed by serology or molecular biology, mild and severe HCPS were compared.139 Chilean patients were analyzed, 64 (46%) with severe disease among which 12 (19 %) died. Results: European ethnicity had 5,1 times higher risk than Amerindian ethnic group to develop a severe HCPS, greater seriousness that was also associated with an urban residence. Conclusion: It was observed that ethnicity and type of residence were significant risk factors for HCPS severity. Hypotheses explaining these findings are discussed.
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