Vol. 36 No. 6 (2019): Diciembre
Vacunología

Active surveillance of febrile seizures associated to DPT vaccines in a sentinel hospital in Uruguay

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  • Carlos Zunino,
  • Germán Botto,
  • Beatriz Gamio,
  • Karina Malan,
  • Noelia Speranza,
  • Rafael Alonso,
  • Salomé Fernández,
  • Adriana Varela,
  • Teresa Picón,
  • Gustavo Giachetto
Carlos Zunino
Hospital Pereira Rossell. Clínica Pediátrica "C". Facultad de Medicina. Universidad de la República. Uruguay
Germán Botto
Departamento Métodos Cuantitativos, Facultad de Medicina Universidad de la República.
Beatriz Gamio
Hospital Pereira Rossell. Clínica Pediátrica "C". Facultad de Medicina. Universidad de la República. Uruguay
Karina Malan
Hospital Pereira Rossell. Clínica Pediátrica "C". Facultad de Medicina. Universidad de la República. Uruguay
Noelia Speranza
Unidad de Inmunizaciones, División Epidemiología, Ministerio Salud. Uruguay
Rafael Alonso
Departamento Métodos Cuantitativos, Facultad de Medicina Universidad de la República.
Adriana Varela
Unidad de Inmunizaciones, División Epidemiología, Ministerio Salud. Uruguay
Teresa Picón
Unidad de Inmunizaciones, División Epidemiología, Ministerio Salud. Uruguay
Gustavo Giachetto
Hospital Pereira Rossell. Clínica Pediátrica "C". Facultad de Medicina. Universidad de la República. Uruguay

Published 2020-01-18

Keywords

How to Cite

1.
Zunino C, Botto G, Gamio B, Malan K, Speranza N, Alonso R, Fernández S, Varela A, Picón T, Giachetto G. Active surveillance of febrile seizures associated to DPT vaccines in a sentinel hospital in Uruguay. Rev. Chilena. Infectol. [Internet]. 2020 Jan. 18 [cited 2026 Feb. 6];36(6). Available from: https://revinf.cl/index.php/revinf/article/view/418

Copyright (c) 2020 Carlos Zunino, Germán Botto, Beatriz Gamio, Karina Malan, Noelia Speranza, Rafael Alonso, Salomé Fernández, Adriana Varela, Teresa Picón, Gustavo Giachetto

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Background: Febrile seizures are VAERS often associated with whole-cells Diphtheria-Pertussis-Tetanus vaccines. Aim: To analyze the association of febrile seizures with the administration of pentavalent vaccine in children under two-years-old assisted in the Centro Hospitalario Pereira Rossell (CHPR), in Montevideo during 2014. Methods: Self-controlled case series study. We included children from Montevideo from two to 24-month-old at the time of admission, with diagnosis of febrile seizure at the time of discharge. We estimated the relative risk in three time periods: 0 to 3 days (risk period), 4 to 14 days (wash-out) and more than 14 days after vaccination (norisk). Results: We recorded 135 febrile seizures in 114 children, 16 of whom presented two or more events. The total number of events was 7 (5.2%) in risk periods and 8 (5.9%) in wash-out periods. The risk period showed a significantly increased risk (RR = 4.14, CI 95% = [1.73; 8.36]). Conclusions: This work allowed us to establish a national base line for the risk of febrile seizures associated with pentavalent vaccination, by using for the first time in the country a methodology specifically designed for this goal.
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