Vol. 36 No. 4 (2019): August
Clinical Research

Prevalence of extended-spectrum beta-lactamases in enterobacteria of neonatal sepsis and associated factors

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  • Juan Carlos Lona-Reyes,
  • René Oswaldo Pérez-Ramírez,
  • Virginia Rodríguez-Patiño,
  • Araceli Cordero-Zamora,
  • Larissa María Gómez-Ruiz,
  • Leonardo Llamas-Ramos
Juan Carlos Lona-Reyes
Hospital Civil de Guadalajara "Dr. Juan I. Menchaca"
Bio
René Oswaldo Pérez-Ramírez
Hospital Civil de Guadalajara "Dr. Juan I. Menchaca"
Virginia Rodríguez-Patiño
Hospital Civil de Guadalajara "Dr. Juan I. Menchaca"
Araceli Cordero-Zamora
Hospital Civil de Guadalajara "Dr. Juan I. Menchaca"
Larissa María Gómez-Ruiz
Hospital Civil de Guadalajara "Dr. Juan I. Menchaca"
Leonardo Llamas-Ramos
Hospital Civil de Guadalajara "Dr. Juan I. Menchaca"

Published 2019-08-25

Keywords

How to Cite

1.
Lona-Reyes JC, Pérez-Ramírez RO, Rodríguez-Patiño V, Cordero-Zamora A, María Gómez-Ruiz L, Llamas-Ramos L. Prevalence of extended-spectrum beta-lactamases in enterobacteria of neonatal sepsis and associated factors. Rev. Chilena. Infectol. [Internet]. 2019 Aug. 25 [cited 2025 Dec. 3];36(4). Available from: https://revinf.cl/index.php/revinf/article/view/51

Copyright (c) 2019 Juan Carlos Lona-Reyes, René Oswaldo Pérez-Ramírez, Virginia Rodríguez-Patiño, Araceli Cordero-Zamora, Larissa María Gómez-Ruiz, Leonardo Llamas-Ramos

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Background: Infections caused by extended-spectrum beta-lactamases enterobacteria (ESBL-EP) have implications for neonatal morbidity and mortality. Aim: To describe the prevalence of ESBL-EP in neonatal sepsis and associated factors. Methods: A prospective cohort study was conducted from August 2016 to August 2017; newborn babies (NB) hospitalized in the Hospital Civil de Guadalajara “Dr. Juan I. Menchaca” were included. The ESBL-EP were investigated by double-disk synergy test and its association with clinical and demographic characteristics of the NB. Results. A total of 1,501 hospitalized NB were studied, with an average gestational age of 36.3 weeks. They were diagnosed 196 neonatal sepsis events, the most frequent etiologies were enterobacteria (45.5%). Resistance to ampicilin was found in 88.8% and to broad spectrum cephalosporins in more than 42% of the strains; 22.9% of them were ESBL phenotype. Apgar ≤ 7 at five minutes of life (OR 4.6; 95% CI 1.47-14.6) and gestational age < 37 weeks (OR 5.4; 95% CI 1.04-27.) increase the risk. Conclusion: In enterobacteria that cause neonatal sepsis, 22.9% were EP-ESBL; infection was more likely in patients with Apgar ≤ 7 at five minutes of age and in preterm infants.
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