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Levels of 25 hydroxy vitamin D of serum and broncho-alveolar lavage in patients with pulmonary tuberculosis
Published 2021-03-20
How to Cite
Copyright (c) 2021 Christian Felipe Ramirez-Ramos, Jhon Fredy Salamanca-Montilla, Emilio Herrera-Céspedes, Juan Diego Rivera-Marín, Paula Ximena Losada-Vanegas, Juan David Areiza-Paramo, David Ricardo Gutierrez-Ramírez, Nicolás Becerra-Meneces, Jorge Luis Méndez-Díaz, María Isabel Cuellar Azuero, Alejandro Pinzón-Tovar, Giovani Lastra-González, Guido Lastra-Lastra
This work is licensed under a Creative Commons Attribution 4.0 International License.
Abstract
Background: Alteration of vitamin D is a risk factor for tuberculosis (TB). Aim: To evaluate the pulmonary and serum levels of 25- hydroxy vitamin D (25OHD) in patients with and without pulmonary TB.
Methods: Two-stage study: the first part was retrospective crosssectional and the second prospective. Those > 18 years of age who underwent fiberoptic bronchoscopy for suspected pulmonary TB and in whom the infection was confirmed were included. Patients with another type of infection without TB and non-infectious diseases were taken as controls for the first stage and infectious controls without TB in the prospective phase. The measurement of 25OHD was performed by ELFA (enzyme-linked fluorescence assay). The Kruskal-Wallis test was used to evaluate association, considering a value of p < 0.05 to be significant. The data were processed with the SPSS version 23 program.
Results: The total sample was 77 patients (35 in the first stage and 42 in the second). The characteristics between the groups were homogeneous. Serum (second phase) and broncho-alveolar lavage (first and second phase) levels of 25OHD were lower in TB patients compared to controls and were independent of serum calcium level (serum: 22.4 ng/mL vs 33 ng/mL, p = 0.006 and broncho-alveolar lavage: 9.7 ng/mL vs 12.2 ng/mL; p = 0.012).
Conclusions: There was a significant difference between the levels of 25OHD in both serum and broncho-alveolar lavage in patients with pulmonary TB in relation to their controls.