Vol. 39 No. 3 (2022): JUNIO
Original Article

Statins and influenza mortality: systematic review and meta-analysis

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  • Walter Masson,
  • Martin Lobo,
  • Augusto Lavalle-Cobo,
  • Gerardo Masson,
  • Graciela Molinero,
  • Melina Huerín
Walter Masson
Hospital Italiano de Buenos Aires
Martin Lobo
Hospital Militar Campo de Mayo
Augusto Lavalle-Cobo
Sanatorio Finochietto
Gerardo Masson
Sanatorio Las Lomas
Graciela Molinero
Sociedad Argentina de Cardiología
Melina Huerín
Instituto Cardiovascular Lezica

Published 2022-08-02

Keywords

How to Cite

1.
Masson W, Lobo M, Lavalle-Cobo A, Masson G, Molinero G, Huerín M. Statins and influenza mortality: systematic review and meta-analysis. Rev. Chilena. Infectol. [Internet]. 2022 Aug. 2 [cited 2026 May 19];39(3). Available from: https://revinf.cl/index.php/revinf/article/view/976

Copyright (c) 2022 Walter Masson, Martin Lobo, Augusto Lavalle-Cobo, Gerardo Masson, Graciela Molinero, Melina Huerín

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Background: Due to their anti-inflammatory properties, it has been suggested that the use of statins could influence the evolution of influenza virus infection. Aim: To evaluate the effect of statin therapy on mortality from influenza. Methods: A meta-analysis that included studies evaluating the use of statins in patients with influenza and reporting data on mortality, after searching the PubMed/MEDLINE, Embase, and Cochrane Controlled Trials databases, was performed. A random effects model was applied. The risk of bias was analyzed and a sensitivity analysis was performed. Results: Eight studies (10 independent cohorts), which included a total of 2,390,730 patients, were identified and eligible for analysis. A total of 1,146,995 subjects analyzed received statins, while 1,243,735 subjects were part of the control group. Statin therapy was associated with lower mortality (OR: 0.66; 95% CI: 0.51-0.85). The sensitivity analysis showed that the results were robust. Conclusions: Our data suggest that, in a population with influenza, the use of statins was associated with a significant reduction in mortality. These results must be confirmed in future clinical trials.

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