Vol. 43 No. 3 (2026): June (Next Issue)
Short Communication

Five consecutive adverse reactions to different antimicrobials and by different mechanisms in the same patient

  • Alberto Fica Cubillos,
  • Monica Kyonen,
  • Lily Acuña Gutierrez,
  • Katherine Illanes,
  • Loreto Carrasco
Alberto Fica Cubillos
Hospital Regional Valdivia
Monica Kyonen
Servicio Farmacia, Hospital Base de Valdivia
Lily Acuña Gutierrez
Servicio Farmacia, Hospital Base de Valdivia
Katherine Illanes
Servicio de Medicina, Hospital Base de Valdivia
Loreto Carrasco
Laboratorio de Histocompatibilidad, Hospital Base de Valdivia

Published 2026-05-26

Keywords

How to Cite

1.
Fica Cubillos A, Kyonen M, Acuña Gutierrez L, Illanes K, Carrasco L. Five consecutive adverse reactions to different antimicrobials and by different mechanisms in the same patient. Rev. Chilena. Infectol. [Internet]. 2026 May 26 [cited 2026 Jun. 14];43(3). Available from: https://revinf.cl/index.php/revinf/article/view/2659

Copyright (c) 2026 Alberto Fica Cubillos, Monica Kyonen, Lily Acuña Gutierrez, Katherine Illanes, Loreto Carrasco

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

We present the case of a 38-year-old male patient who was admitted for opportunistic infections associated with AIDS. He evolved with five adverse reactions to different antimicrobials in a sequential manner: hyponatremia and acute kidney injury due to cotrimoxazole, hepatitis due to tenofovir, skin rash secondary to primaquine, neutropenia by valganciclovir and a drug reaction with eosinophilia and systemic symptoms (DRESS) related to dapsone. Some of these adverse reactions are exceptional, such as dapsone-related DRESS and hepatitis by tenofovir. Two events were serious and all of them required modification of therapies and prophylaxis. Three of these reactions were considered to have a definitive causality according to WHO criteria and two were considered probable. The patient evolved favorably to all of them.